BioEVAL: A global, multi-institutional benchmark of large language and multimodal models for bioengineering

Computer Science > Artificial Intelligence

[Submitted on 24 Sep 2026]

Title:BioEVAL: A global, multi-institutional benchmark of large language and multimodal models for bioengineering

View PDFAbstract:Large Language Models (LLMs) have demonstrated historic breakthroughs in general reasoning with early successes in biomedical science. However, existing LLM benchmarking emphasizes factual recall, offering limited insight into model performance on frontier and multimodal tasks. We assembled BioEVAL (BioEngineering Validation of AI and LLMs), a global, multi-institutional initiative designed to assess experimental reasoning capability across bioengineering (BE) subfields. BioEVAL spans 11 major BE subfields plus a set of uncategorized items, bringing together 22 research groups to create a PhD-level benchmark comprising 608 evaluation items: 1) 380 multiple-choice questions (MCQs, 359 retained after audit), 2) 218 literature synthesis tasks, and 3) 10 multimodal problems with experimental image interpretation. Benchmark items underwent authoring-group expert review and centralized quality control before evaluation. Following evaluation, a blinded cross-group consensus audit of the highest- and lowest-accuracy MCQ items flagged 21 questions for revision or removal; these were withheld, and all reported MCQ results are computed on the 359 retained items. We evaluated diverse cloud-scale foundation/multimodal models (e.g., ChatGPT, Gemini, and Grok) and locally deployable models suitable for inference on consumer-grade GPUs. Models achieved the highest accuracy of up to 90% on MCQs, similarity score of 0.72 on literature synthesis, and accuracy of 80% on a small sample of multimodal reasoning questions, with substantial performance variation across subfields. Leaderboard rankings characterize current capabilities, limitations, and development priorities across the evaluated BE task categories. BioEVAL is maintained as an extensible benchmark with standardized protocols for continuing expert item contribution and model evaluation.

Submission history

From: Vinny Chandran Suja [view email][v1] Thu, 24 Sep 2026 19:26:39 UTC (6,636 KB)

References & Citations

Loading...

Bibliographic and Citation Tools

Bibliographic Explorer (What is the Explorer?)

Connected Papers (What is Connected Papers?)

Litmaps (What is Litmaps?)

scite Smart Citations (What are Smart Citations?)

Code, Data and Media Associated with this Article

alphaXiv (What is alphaXiv?)

CatalyzeX Code Finder for Papers (What is CatalyzeX?)

DagsHub (What is DagsHub?)

Gotit.pub (What is GotitPub?)

Hugging Face (What is Huggingface?)

ScienceCast (What is ScienceCast?)

Demos

Recommenders and Search Tools

Influence Flower (What are Influence Flowers?)

CORE Recommender (What is CORE?)

arXivLabs: experimental projects with community collaborators

arXivLabs is a framework that allows collaborators to develop and share new arXiv features directly on our website.

Both individuals and organizations that work with arXivLabs have embraced and accepted our values of openness, community, excellence, and user data privacy. arXiv is committed to these values and only works with partners that adhere to them.

Have an idea for a project that will add value for arXiv's community? Learn more about arXivLabs.