Driving Epidemic Models with AI Agents: the Epydemix Agent FrameworkDriving Epidemic Models with AI Agents: the Epydemix Agent Framework

Computer Science > Artificial Intelligence

[Submitted on 23 Sep 2026]

Title:Driving Epidemic Models with AI Agents: the Epydemix Agent Framework

View PDF HTML (experimental)Abstract:Artificial Intelligence agents based on large language models provide convenient natural language interfaces to scientific software, but reliability is not automatic. Here we introduce the Epydemix Agent Framework, an additive layer over Epydemix, an open-source Python library for stochastic compartmental epidemic modeling. The framework extends the library with four capabilities to facilitate interaction with an AI agent: discovery of available models and parameters, preventive validation of a declarative scenario specification, execution through tested library code, and inspectability of results. These capabilities let an agent handle the entire modeling process, from the natural-language description of the scenario to quantitative results, figures, and interpretation of findings without writing custom code. Each step reads input files and saves results in a separate output bundle, making the process auditable and reproducible. First, we show the end-to-end workflow with a case study comparing vaccination strategies for a novel respiratory virus. Second, we assessed the framework across 50 agent sessions and five modeling tasks by comparing the agent use of the framework against the direct use of the Python interface. The framework reduced turns, output tokens, and cost on most tasks, unless it trades resources for per-point reproducibility.

References & Citations

Loading...

Bibliographic and Citation Tools

Bibliographic Explorer (What is the Explorer?)

Connected Papers (What is Connected Papers?)

Litmaps (What is Litmaps?)

scite Smart Citations (What are Smart Citations?)

Code, Data and Media Associated with this Article

alphaXiv (What is alphaXiv?)

CatalyzeX Code Finder for Papers (What is CatalyzeX?)

DagsHub (What is DagsHub?)

Gotit.pub (What is GotitPub?)

Hugging Face (What is Huggingface?)

ScienceCast (What is ScienceCast?)

Demos

Recommenders and Search Tools

Influence Flower (What are Influence Flowers?)

CORE Recommender (What is CORE?)

arXivLabs: experimental projects with community collaborators

arXivLabs is a framework that allows collaborators to develop and share new arXiv features directly on our website.

Both individuals and organizations that work with arXivLabs have embraced and accepted our values of openness, community, excellence, and user data privacy. arXiv is committed to these values and only works with partners that adhere to them.

Have an idea for a project that will add value for arXiv's community? Learn more about arXivLabs.